Volume 4, Issue 1

Molecular Chaperone GroEL – toward a Nano Toolkit in Protein Engineering, Production and Pharmacy

Alexey N. Fedorov and Maria S. Yurkova
In this review, we discuss the potential of molecular chaperones belonging to GroEL family as applied to different practical uses. The GroEL, often referred to as chaperonin, plays a fundamental role in protein folding in cells and is essential for the proper folding of a number of proteins. Early on in studying chaperones it has been considered, along with other chaperones, as an attractive tool to assist recombinant protein folding in cells and their refolding in vitro.

Read More

Special Article of Prof. Nicolini 75th Birthday, Editor-in-Chief NanoWorld Journal

Andrew Belmont, Michael Eldarov, Eugenia Pechkova, Christian Riekel and Francesco Sette
I was a MD, Ph.D. student with Dr. Nicolini during the late 1970s and early 1980s at Temple University.
As a newly admitted medical student, I still remember engaging in small talk with a former lab member turned dental student, Elliot Milgram, while anxiously awaiting my interview with Dr. Nicolini for a summer research position in the laboratory.

Read More